![]() ![]() ![]() The potassium ion (K +) concentration is much higher in the ICF than in the ECF.The most important difference between the ICF and the ECF is the relative concentration of cations (positively charged ions): The composition of ions between the fluid compartments varies, but within any one compartment, electrical neutrality is maintained with the total number of positive charges always being equal to the total number of negative charges. Fluids leaking from the peritoneal cavity, e.g.Third spacing is the unusual accumulation of fluid in the transcellular space. The barrier between the interstitial fluid and the intravascular fluid consists of the walls of capillaries. Transcellular fluid: This is the final 1.5 L of fluid and comprises intraocular fluid, cerebrospinal fluid, urine in the bladder, and fluid within the lumen of the bowel.Intravascular fluid: This is the plasma, which is the liquid component of the blood and accounts for approximately 25% of the ECF (3.5 L of fluid).Interstitial fluid (ISF): This is the tissue fluid found in the spaces between the cells and accounts for approximately 65% of the ECF (10 L of fluid).The extracellular fluid is further divided into three other compartments: These compartments are separated by the plasma membrane of the cells and differ markedly in terms of the concentrations of the ions dissolved in them. Extracellular fluid (ECF): This is the water outside of the cells and accounts for approximately 35% of total body water (15 L of fluid).This is the matrix in which intracellular organelles are suspended, and chemical reactions take place. Intracellular fluid (ICF): This is the water within the cells and accounts for approximately 65% of total body water (30 L of fluid).There are two major fluid compartments in the human body: Total body water (TBW) accounts for around 60% of an adult male’s total body weight a normally hydrated 75 kg man will consist of approximately 45 L of water. ![]() The amount of water in the body varies with a patient’s age, weight, and sex. ![]()
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