![]() The tetrahedral geometry of the Cd(II) complex was confirmed using UV-Visible spectra. The conductivity data confirmed the neutral nature of the complexes. Methods: The data of microanalysis and metal estimation showed that the complexes have the composition of for Cu(II) and for Cd(II) complex respectively. Objective: Mixed ligand complexes of Cu(II) and Cd(II) with 4-aminobenzamide(4-ABZ) have been synthesized under microwave irradiation and they were characterized by elemental analysis, estimation of metal ion, molar conductivity, magnetic study, FT-IR, Far-IR, electronic spectra, NMR (1H and 13C) and EPR spectral studies. It is imperative to conduct advanced studies in this regard for better therapeutic outcomes in the management of such patients. Nanomedicines and nanotechnology based drug delivery systems holds tremendous potential in the management of cognitive impairment in depression as well as other neuropsychiatric disorders. There is a dearth of sufficient studies which focus on cognitive domain in depression. Several new nanomedicines and nanotechnology based drug delivery systems for improving the efficacy of new and old drugs used for the management of cognitive dysfunction in major depressive disorder were reviewed. The information obtained during the literature search aided in comprehending the scenario. Journals, articles, and reports were thoroughly searched for the efficacy and safety of nanotechnology based newer drug delivery approaches for the management of cognitive dysfunction in major depressive disorder. The method entailed a review of research articles, review articles, and other internet-sourced materials. To review and discuss the current therapeutic strategies available for the management of cognitive dysfunction in major depressive disorder with special emphasis on novel therapeutics based on nanotechnology like nano carrier delivery systems. A.: Identification of potential inhibitor targeting InhA, molecular docking, ADMET, molecular dynamic simulation and antibacterial activity of thiazolidinone derivatives: A computational approach. Compound 12 is utilised as an alternate medication for Staphylococcus aureus. Compound 12's antibacterial activity against Staphylococcus aureus is compared to Ampicillin and Cefixime. Molecular docking studies examining the inhibitory effect of produced substances suggest testing for MIC antibacterial activity. MIC screening of synthesised thiazolidinone derivatives against Staphylococcus aureus through disc diffusion. Molecular docking, ADMET, TOPKAT Toxicity, and molecular dynamic simulation were used to estimate drug-likeness for 1QG6. ![]() Five 4-thiazolidinone derivatives:4-(4-oxo-2-phenylthiazolidin-3yl)amino)benzyl)oxazolidin-2-one(8), ((2-(4-chlorophenyl)-4oxothiazolidin-3yl)amino)benzyl)-oxazolidin-2-one(9), ((2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)amino)benzyl)oxazolidin-2-one(10), 4-(4-((4-oxo-2-(p-tolyl)thiazolidin-3yl)amino)benzyl)oxazolidin-2-one(11) and 4-(4-((2-(4-methoxyphenyl)-4-oxothiazolidin-3yl)amino)benzyl)oxazolidin-2-one(12) docked due to its vast biological usefulness. Bruker obtained 400 MHz 1H spectra of all chemicals in DMSO-d6. ![]() KBr pellet FT-IR spectra were collected on a Thermo Nicolet AVATAR-330 spectrometer. MIC screening produced thiazolidinone derivatives for Staphylococcus aureus illness. This study was performed to examine molecular docking of newly synthesised thiazolidinone compounds and discover potential InhA inhibitors. ![]()
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